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Paraneoplastic retinopathy associated with retroperitoneal liposarcoma

Authors Mineo Kondo, Kumiko Mokuno, Ai Uemura, et al

Published 30 March 2010 Volume 2010:4 Pages 243—245

DOI https://doi.org/10.2147/OPTH.S9312

Review by Single-blind

Peer reviewer comments 3

Mineo Kondo1, Kumiko Mokuno2, Ai Uemura1, Shu Kachi1, Makoto Nakamura1, Atsuya Kondo3, Hiroko Terasaki1

1Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan; 2Department of Ophthalmology, 3Department of Urology, Kariya Toyota General Hospital Kariya, Japan

Abstract: We report a case of paraneoplastic retinopathy associated with a retroperitoneal liposarcoma. A 42-year-old man was referred to our hospital with complaints of night blindness and blurred vision in the peripheral field. Electroretinograms showed a progressive amplitude reduction in his both eyes. Abdominal magnetic resonance imaging showed a large retroperitoneal mass, and pathologic examination revealed a dedifferentiated liposarcoma. Western blot analysis showed an antiretinal antibody in the serum of our patient, and his serum reacted with the photoreceptors of a bovine retina. To the best of our knowledge, this is the first case of paraneoplastic retinopathy associated with a liposarcoma.

Keywords: paraneoplastic retinopathy, retroperitneal liposarcoma, electroretinogram, cancerassociated retinopathy

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