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Pain management in patients with malignant mesothelioma: challenges and solutions

Authors Saunders J, Ashton M, Hall C, Laird B, MacLeod N

Received 29 October 2018

Accepted for publication 22 January 2019

Published 2 April 2019 Volume 2019:10 Pages 37—46

DOI https://doi.org/10.2147/LCTT.S192558

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Andrew Yee

Peer reviewer comments 2

Editor who approved publication: Dr Sai-Hong Ignatius Ou


J Saunders,1 M Ashton,1,2 C Hall,3,4 B Laird,3,4 N MacLeod1

1Beatson West of Scotland Cancer Centre, Glasgow G12 0YN, UK; 2Institute of Cancer Sciences, University of Glasgow, UK; 3Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XR, UK; 4St Columba’s Hospice, Edinburgh EH5 3RW, UK

Abstract: Malignant pleural mesothelioma (MPM) is an aggressive cancer with a considerable symptom burden and poor prognosis. Focus on maintaining patients’ quality of life and pain control is therefore paramount. Pain management in MPM is complex due to its multifactorial etiology resulting from direct tumor infiltration of the surrounding soft tissue, bone, and encasement of the intercostal nerves. A variety of treatment modalities, including pharmacological and non-pharmacological options, are often required to achieve adequate pain control in this challenging disease. This review article examines the current challenges and solutions available for pain management in MPM.

Keywords: malignant, pleural, mesothelioma, pain, radiotherapy
 

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