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Paclitaxel- and/or cisplatin-induced ocular neurotoxicity: a case report and literature review

Authors Li Y, Li Y, Li J, Pi G, Tan W

Received 8 April 2014

Accepted for publication 13 May 2014

Published 31 July 2014 Volume 2014:7 Pages 1361—1366

DOI https://doi.org/10.2147/OTT.S65774

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3


Ying Li* Yanping Li* Junyu Li , Guoliang Pi, Wenyong Tan

Department of Radiation Oncology, Hubei Cancer Hospital, Wuhan, People's Republic of China

*These authors contributed equally to this work

Abstract: Paclitaxel (PTX) and/or cisplatin (CDDP), as important cytotoxic anti-cancer agents, are widely used to treat various solid tumors. Both may cause moderate or severe neurotoxicity, but ocular neurotoxicity is also occasionally reported. A patient diagnosed with nasopharyngeal cancer suffering acute ocular neurotoxicity 10 days after paclitaxel and CDDP administration at the recommended dose is described in the present case report, and PTX- and/or CDDP-induced ocular neurotoxicity are summarized according to previous reports. Possible mechanisms and the potential diagnostic, therapeutic and predictive strategies of PTX- and/or CDDP-induced ocular neurotoxicity are reviewed, to help the oncologist to take the infrequent toxicity of cytotoxic drugs into account and improve patient safety during anti-cancer therapy.

Keywords: cytotoxic drugs, PTX, CDDP, oncology, chemotherapy

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