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Oxygen therapy in acute exacerbations of chronic obstructive pulmonary disease

Authors Brill SE, Wedzicha JA

Received 31 July 2014

Accepted for publication 4 September 2014

Published 7 November 2014 Volume 2014:9(1) Pages 1241—1252

DOI https://doi.org/10.2147/COPD.S41476

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 5

Editor who approved publication: Dr Richard Russell

Simon E Brill, Jadwiga A Wedzicha

Airway Disease Section, National Heart and Lung Institute, Imperial College, London, UK

Abstract: Acute exacerbations of chronic obstructive pulmonary disease (COPD) are important events in the history of this debilitating lung condition. Associated health care utilization and morbidity are high, and many patients require supplemental oxygen or ventilatory support. The last 2 decades have seen a substantial increase in our understanding of the best way to manage the respiratory failure suffered by many patients during this high-risk period. This review article examines the evidence underlying supplemental oxygen therapy during exacerbations of COPD. We first discuss the epidemiology and pathophysiology of respiratory failure in COPD during exacerbations. The rationale and evidence underlying oxygen therapy, including the risks when administered inappropriately, are then discussed, along with further strategies for ventilatory support. We also review current recommendations for best practice, including methods for improving oxygen provision in the future.

Keywords: chronic obstructive pulmonary disease (COPD), exacerbation, oxygen therapy, respiratory failure, hypercapnia

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