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Overview of the genetic basis toward early detection of breast cancer

Authors De Silva S, Tennekoon KH, Karunanayake EH

Received 30 August 2018

Accepted for publication 7 December 2018

Published 21 January 2019 Volume 2019:11 Pages 71—80

DOI https://doi.org/10.2147/BCTT.S185870

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Andrew Yee

Peer reviewer comments 2

Editor who approved publication: Professor Pranela Rameshwar


Sumadee De Silva, Kamani Hemamala Tennekoon, Eric Hamilton Karunanayake

Institute of Biochemistry, Molecular Biology and Biotechnology, University of Colombo, Colombo, Sri Lanka

Abstract: Cancer is a socioeconomical burden in any nation. Out of that, breast cancer is identified as the most common malignancy worldwide among women irrespective of age. As women are an important segment in a community, the weakening of their strength toward the development of a nation is a critical problem in each nation. In this review, it was aimed to discuss the characteristics of cancer genome, cancer genetics, and cancer epigenetics in general and then focus on discussing both genetic and nongenetic factors responsible for the predisposition of breast cancer in humans. More emphasis was placed on genes responsible for the early onset of the disease and which can be used as genetic tools in the identification of the disease at an early stage. Then the context of genetic involvement toward the breast cancer occurrence before age of 40 years was highlighted accordingly. In addition to genetic testing, the review paid adequate attention to mention novel liquid biopsy techniques and other clinical, laboratory, and radiologic assessments. These techniques can be used in early detection and recurrence as well as the surveillance of the patients after primary therapies.

Keywords: breast cancer, genetic predisposition, early onset, recurrence
 

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