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Overview of microRNA-199a Regulation in Cancer

Authors Wang Q, Ye B, Wang P, Yao F, Zhang C, Yu G

Received 21 September 2019

Accepted for publication 23 November 2019

Published 10 December 2019 Volume 2019:11 Pages 10327—10335

DOI https://doi.org/10.2147/CMAR.S231971

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Eileen O'Reilly


Qiwen Wang,1,2,* Bingyu Ye,1,2,* Ping Wang,1,2 Fenjie Yao,1,2 Chunyan Zhang,1,2 Guoying Yu1,2

1Henan International Joint Laboratory of Pulmonary Fibrosis, College of Life Science, Henan Normal University, Xinxiang 453007, Henan, People’s Republic of China; 2State Key Laboratory Cell Differentiation and Regulation, College of Life Science, Henan Normal University, Xinxiang 453007, People’s Republic of China

*These authors contributed equally to this work

Correspondence: Chunyan Zhang; Guoying Yu
College of Life Science, Henan Normal University, 46# East of Construction Road, Xinxiang, Henan 453007, People’s Republic of China
Tel +86 373 3325654; +86 373 3326001
Fax +86 373 3326524
Email zcy1119sdc@163.com; guoyingyu@htu.edu.cn

Abstract: microRNAs (miRNAs) are a class of endogenous short, non-coding RNAs that regulate a multitude of genes at the post-transcriptional level. miR-199, which is a highly conserved miRNA family, consists of miR-199a and miR-199b. Researchers mainly focused on miR-199a over the past few years. Functional studies have demonstrated that mature miR-199a is a key player in the maintenance of normal homeostasis and in the regulation of disease pathogenesis. Here, we summarize the biological functions of miR-199a and review recent research on its roles in the physiological processes of cancer cells, such as proliferation, migration, invasion, apoptosis, autophagy and glycometabolism.

Keywords: microRNA-199a, target genes, carcinoma, biomarker, regulatory mechanisms

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