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Overview of ethical issues for conducting neuroprotective clinical trials in patients with spinal cord injury

Authors Saberi H, Derakhshanrad N, Ghajarzadeh M

Received 14 November 2014

Accepted for publication 21 March 2015

Published 6 May 2015 Volume 2015:3 Pages 97—100

DOI https://doi.org/10.2147/JN.S74137

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Prof. Dr. Hari Shanker Sharma


Hooshang Saberi,1,2 Nazi Derakhshanrad,1 Mahsa Ghajarzadeh1

1Brain and Spinal Cord Injury Research Center, Imam Khomeini Hospital, 2Department of Neurosurgery, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran

Abstract: Animals have been used in medical and biological researches worldwide for long time. Almost all of these studies are published with the hope of clinical application. However, there are meticulous criteria considering results of animal studies in clinical trials of human beings. In recent years, the number of experimental research in animal models of spinal cord injury has been growing. However, there is no warranty for translation of experimental studies into clinical practice. Certain protocols should be considered in all phases of conducting clinical trials such as study design, data gathering, and analysis. In this article, we comprehensively review different aspects of ethical issues in translating results of animal studies into clinical application, especially in patients with spinal cord injury.

Keywords: neuroprotective treatment, spinal cord injury, animal studies, translation

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