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Overview of clinical use and side effect profile of valsartan in Chinese hypertensive patients

Authors Huang QF, Li Y, Wang JG

Received 30 August 2013

Accepted for publication 5 November 2013

Published 30 December 2013 Volume 2014:8 Pages 79—86

DOI https://doi.org/10.2147/DDDT.S38617

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Qi-Fang Huang, Yan Li, Ji-Guang Wang

Centre for Epidemiological Studies and Clinical Trials, The Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China

Abstract: We reviewed the Chinese and English literature for the efficacy and safety data of valsartan monotherapy or combination therapy in Chinese hypertensive patients. According to the data of ten randomized controlled trials, valsartan monotherapy was as efficacious as another angiotensin receptor blocker or other classes of antihypertensive drugs, excepting the slightly inferior diastolic blood pressure-lowering effect in comparison with calcium channel blockers. According to the data of six randomized controlled trials, valsartan combination, with hydrochlorothiazide, amlodipine, or nifedipine gastrointestinal therapeutic system, was more efficacious than monotherapy of valsartan, amlodipine, or nifedipine gastrointestinal therapeutic system. According to these trials, valsartan had an acceptable tolerability, regardless of whether it was used as monotherapy or in combination therapy. Nonetheless, several rare side effects have been reported, indicating that it should still be used with caution. This is of particular importance given that there are millions of hypertensive patients, worldwide, currently exposed to the drug.

Keywords: angiotensin receptor blocker, valsartan, hypertension, blood pressure, efficacy, side effect

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