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Overview of 99mTc-anti-TNF-α scintigraphy: diagnostic applications

Authors Elboga U, Kalender E, Yalcin H

Received 2 October 2013

Accepted for publication 4 November 2013

Published 19 December 2013 Volume 2014:7 Pages 1—4


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Umut Elboga,1 Ebuzer Kalender,2 Hulya Yalcin2

1Department of Nuclear Medicine, Gaziantep University, Gaziantep, Turkey; 2Department of Nuclear Medicine, Mustafa Kemal University, Antioch, Turkey

Abstract: Tumor necrosis factor alpha (TNF-α) has a role in the pathogenesis of several inflammatory diseases such as rheumatoid arthritis, Crohn’s disease, and ulcerative colitis. As TNF-α plays a role in the pathogenesis of different inflammatory diseases, anti-TNF-α agents (monoclonal antibodies [mAbs]) such as infliximab, adalimumab, and certolizumab have been developed and investigated for the treatment of these conditions. In recent years, these mAbs also have been used for diagnosis, monitoring, follow-up of disease activity, and therapy decision-making for inflammatory diseases, especially rheumatoid arthritis, after labeling with 99mTc. However, 99mTc-anti-TNF-α imaging might have severe adverse effects and is expensive. In contrast, scintigraphic imaging before therapy with radiolabeled mAbs may be a cost-effective solution for therapy decisions.

Keywords: monoclonal antibodies, mAb, nuclear medicine, 99mTc tumor necrosis factor-α imaging

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