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Overlaps and uncertainties of smoking-related idiopathic interstitial pneumonias

Authors Bak SH, Lee HY

Received 20 July 2017

Accepted for publication 9 October 2017

Published 1 November 2017 Volume 2017:12 Pages 3221—3229

DOI https://doi.org/10.2147/COPD.S146899

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Charles Downs

Peer reviewer comments 3

Editor who approved publication: Dr Richard Russell

So Hyeon Bak,1,2 Ho Yun Lee1

1Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, 2Department of Radiology, Kangwon National University Hospital, Chuncheon, Korea

Abstract: Smoking-related interstitial lung disease (ILD) consists of a heterogeneous group of disorders that are considered a distinct entity. The 2013 American Thoracic Society and European Respiratory Society recommendations classified respiratory bronchiolitis (RB)/RB-ILD and desquamative interstitial pneumonia (DIP) as smoking-related idiopathic interstitial pneumonias (IIPs). The overlapping histopathological and radiological patterns of smoking-related IIPs must be considered. Overlap patterns of smoking-related IIPs are not easily classified as a single disorder. The initial radiological manifestation and follow-up changes are heterogeneous, even when diagnosed pathologically as RB or DIP. Therefore, a clinical–radiological–pathological consensus is important in the diagnosis of smoking-related IIPs, and long-term evaluation is essential to monitor the morphological changes in these patients. In this article, we reviewed the clinical, radiological, and pathological findings, and also the changes in radiological manifestations of smoking-related IIPs over time.

Keywords: smoking, diagnosis, biopsy, computed tomography

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