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Overexpression of HDAC9 is associated with poor prognosis and tumor progression of breast cancer in Chinese females

Authors Huang Y, Jian W, Zhao J, Wang G

Received 4 February 2018

Accepted for publication 1 March 2018

Published 17 April 2018 Volume 2018:11 Pages 2177—2184

DOI https://doi.org/10.2147/OTT.S164583

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Ms Justinn Cochran

Peer reviewer comments 2

Editor who approved publication: Dr Carlos E Vigil


Yixiang Huang,* Wei Jian,* Junyong Zhao, Gang Wang

Department of General Surgery, Tenth People’s Hospital of Tongji University, Shanghai, China

*These authors contributed equally to this work

Background: Breast cancer represents a serious health issue among females. HDAC9 has been identified as an oncogene in human cancers. This study sought to assess the prognostic value and the biologic function of HDAC9 in breast cancer patients.
Methods: Expression of HDAC9 in breast cancer tissues and cells was evaluated by quantitative real-time polymerase chain reaction. Kaplan–Meier survival analysis and Cox regression assay were conducted to explore the prognostic significance of HDAC9. Cell experiments were performed to investigate the effects of HDAC9 on the biologic behaviors of breast cancer cells.
Results: Expression of HDAC9 was significantly upregulated in both cancerous tissues and cells compared with the normal controls (all P<0.05). Overexpression of HDAC9 was correlated with lymph node metastasis (P=0.021) and TNM stage (P=0.004). Patients with high HDAC9 had poor overall survival compared to those with low levels of HDAC9 (log-rank P<0.05). Elevated HDAC9 was found to be an independent prognostic factor for the patients (hazard ratio=2.996, 95% CI=1.611–5.572, P=0.001). According to the cell experiments, tumor cell proliferation, migration and invasion were suppressed by knockdown of HDAC9.
Conclusion: All data demonstrated that overexpression of HDAC9 serves as a prognostic biomarker and may be involved in the tumor progression of breast cancer.

Keywords:
HDAC9, prognosis, progression, breast cancer

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