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Ovarian teratoma: yet another cause of immune thrombocytopenia

Authors Khalife D, Nassif J, Khalil A, Ghazeeri G, Taher A

Received 23 July 2018

Accepted for publication 3 September 2018

Published 4 October 2018 Volume 2018:10 Pages 567—570

DOI https://doi.org/10.2147/IJWH.S181134

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Andrew Yee

Peer reviewer comments 3

Editor who approved publication: Professor Elie Al-Chaer


Dalia Khalife,1 Joseph Nassif,1 Ali Khalil,1 Ghina Ghazeeri,1 Ali Taher2

1Department of Obstetrics and Gynecology, American University of Beirut Medical Center, Beirut, Lebanon; 2Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon

Abstract: A hematologic disorder occurred simultaneously with an ovarian cystic teratoma in a young woman. The blood disorder was a severe thrombocytopenia, with no spontaneous remission, or improvement after steroids tapering. To date, this is the second report in literature of immune thrombocytopenia associated with an ovarian teratoma, completely resolving following surgical excision of the ovarian teratoma. This case may suggest a potential peptide secreted by the ovarian teratoma toxic to platelets, and or a genetic predisposition in patients displaying the syndrome. Further research is needed in this area to highlight the mechanism of association.

Keywords: mature ovarian teratoma, immune thrombocytopenia purpura, laparoscopic surgery

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