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Ovarian cancer: emerging molecular-targeted therapies

Authors Sourbier C

Received 10 March 2012

Accepted for publication 13 April 2012

Published 20 June 2012 Volume 2012:6 Pages 147—154

DOI https://doi.org/10.2147/BTT.S24155

Review by Single-blind

Peer reviewer comments 2


Carole Sourbier

Rockville, MD, USA

Abstract: With about 22,000 new cases estimated in 2012 in the US and 15,500 related deaths, ovarian cancer is a heterogeneous and aggressive disease. Even though most of patients are sensitive to chemotherapy treatment following surgery, recurring disease is almost always lethal, and only about 30% of the women affected will be cured. Thanks to a better understanding of the molecular mechanisms underlying ovarian cancer malignancy, new therapeutic options with molecular-targeted agents have become available. This review discusses the rationale behind molecular-targeted therapies and examines how newly identified molecular targets may enhance personalized therapies for ovarian cancer patients.

Keywords: ovarian cancer, angiogenesis, PI3K/Akt, BRCA, metabolism

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