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Outcome results in children with IgA nephropathy: a single center experience

Authors Kaplan Bulut I, Mir S, Sozeri B, Bulut, Sen, Dincel N

Received 30 July 2011

Accepted for publication 7 September 2011

Published 20 January 2012 Volume 2012:5 Pages 23—28


Review by Single-blind

Peer reviewer comments 3

Ipek Kaplan Bulut1, Sevgi Mir1, Betul Sozeri1, Mustafa Orhan Bulut2, Sait Sen3, Nida Dincel1
1Ege University Faculty of Medicine Department of Pediatric Nephrology, 2Ege University Faculty of Medicine Department of Pediatrics, Izmir, 3Ege University Faculty of Medicine Department of Pathology, Izmir, Turkey

Background: Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis. Patients manifest variable clinical symptoms (eg, microhematuria) with preserved or progressive deterioration of renal function resulting in end-stage renal disease. The aim of this study was to evaluate patients from a single center to describe the clinical features, treatments, and follow-up results of those with the disease.
Methods: This is a retrospective data study of all children with IgAN. Patients who had a histopathologically proven diagnosis of IgAN and were followed up for at least 5 years were included in the study. Renal biopsy, graded as Hass classification, was performed on all patients. A total of 39 patients were included in the study.
Results: The mean follow-up time (± standard deviation) was 10.4 ± 3.51 (range 5–16) years. Twenty-nine patients (74.4%) were male and ten (25.6%) were female. Nineteen (48.7%) patients presented with recurrent macroscopic hematuria, ten (25.6%) with microscopic hematuria ± proteinuria, six (15.4%) with nephritic syndrome, and four (10.3%) with nephrotic syndrome. All patients underwent a renal biopsy, which was graded according to the Hass classification. At the end of follow-up time, 18 (46.1%) patients were normal, 15 (38.5%) had minor urinary abnormalities, three (7.7%) had active renal disease, and three (7.7%) developed renal failure.
Conclusion: The results of the present study are better than those from most other series. The majority of children with IgAN in this study were admitted with recurrent macroscopic hematuria and found to have a good prognosis. We suggest that children with IgAN have a good prognosis in the first 5-year follow-up period.

Keywords: immunoglobulin A nephropathy, childhood, prognosis

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