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Osseointegration: a review of the fundamentals for assuring cementless skeletal fixation

Authors Isaacson B, Jeyapalina S

Received 16 December 2013

Accepted for publication 15 January 2014

Published 25 April 2014 Volume 2014:6 Pages 55—65

DOI https://doi.org/10.2147/ORR.S59274

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2


Brad M Isaacson,1,2 Sujee Jeyapalina3,4

1Henry M Jackson Foundation for the Advancement of Military Medicine, 2The Center for Rehabilitation Sciences Research, Department of Physical Medicine and Rehabilitation, Uniformed Services University of Health Sciences, Bethesda, MD, USA; 3Department of Orthopedics, 4Orthopedic Research Laboratory, University of Utah, Salt Lake City, UT, USA

Abstract: Direct skeletal fixation, termed osseointegration, has expanded in the last century and includes use in total joint replacements, the edentulous mandible and maxilla, and percutaneous osseointegrated prosthetics. Although it is well known that titanium and bone have the ability to form a durable bone–implant interface, new applications have emerged in the field of orthopedics, which requires a more thorough assessment of the literature. This review aims to introduce the basic biological principles for attaining osseointegration and discusses the major factors for assuring successful cementless fixation.

Keywords: osseointegration, bone, skeletal attachment, total joint replacements, dental implants, percutaneous


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