Back to Journals » Cancer Management and Research » Volume 5

Orphan G protein receptor GPR55 as an emerging target in cancer therapy and management

Authors Leyva-Illades D, DeMorrow S

Received 2 April 2013

Accepted for publication 19 May 2013

Published 1 July 2013 Volume 2013:5 Pages 147—155


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 4

Dinorah Leyva-Illades,1–3 Sharon DeMorrow1–3

1Digestive Disease Research Center, Scott and White Hospital, Temple, TX, USA; 2Department of Internal MedicineTexas A&M Health Science Center, Temple, TX, USA; 3Research Service, Central Texas Veterans Health Care System, Temple, TX, USA

Abstract: G protein-coupled receptors (GPCRs) modulate a vast array of cellular processes. The current review gives an overview of the general characteristics of GPCRs and their role in physiological conditions. In addition, it describes the current knowledge of the physiological and pathophysiological functions of GPR55, an orphan GPCR, and how it can be exploited as a therapeutic target to combat various cancers.

Keywords: GPR55, cancer, GPCR, endocannabinoids

Creative Commons License © 2013 The Author(s). This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.