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Orphan G protein receptor GPR55 as an emerging target in cancer therapy and management
Authors Leyva-Illades D, DeMorrow S
Received 2 April 2013
Accepted for publication 19 May 2013
Published 1 July 2013 Volume 2013:5 Pages 147—155
DOI https://doi.org/10.2147/CMAR.S35175
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 4
Dinorah Leyva-Illades,1–3 Sharon DeMorrow1–3
1Digestive Disease Research Center, Scott and White Hospital, Temple, TX, USA; 2Department of Internal MedicineTexas A&M Health Science Center, Temple, TX, USA; 3Research Service, Central Texas Veterans Health Care System, Temple, TX, USA
Abstract: G protein-coupled receptors (GPCRs) modulate a vast array of cellular processes. The current review gives an overview of the general characteristics of GPCRs and their role in physiological conditions. In addition, it describes the current knowledge of the physiological and pathophysiological functions of GPR55, an orphan GPCR, and how it can be exploited as a therapeutic target to combat various cancers.
Keywords: GPR55, cancer, GPCR, endocannabinoids
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