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Orchestrating epigenetic roles targeting ocular tumors

Authors Wen X, Lu L, Zhang H, Fan X

Received 7 August 2015

Accepted for publication 7 November 2015

Published 29 February 2016 Volume 2016:9 Pages 1001—1009

DOI https://doi.org/10.2147/OTT.S93995

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Ram Prasad

Peer reviewer comments 3

Editor who approved publication: Professor Jianmin Xu


Xuyang Wen*, Linna Lu*, He Zhang, Xianqun Fan

Department of Ophthalmology, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China

*These authors contributed equally to this work

Abstract: Epigenetics is currently one of the most promising areas of study in the field of biomedical research. Scientists have dedicated their efforts to studying epigenetic mechanisms in cancer for centuries. Additionally, the field has expanded from simply studying DNA methylation to other areas, such as histone modification, non-coding RNA, histone variation, nucleosome location, and chromosome remodeling. In ocular tumors, a large amount of epigenetic exploration has expanded from single genes to the genome-wide level. Most importantly, because epigenetic changes are reversible, several epigenetic drugs have been developed for the treatment of cancer. Herein, we review the current understanding of epigenetic mechanisms in ocular tumors, including but not limited to retinoblastoma and uveal melanoma. Furthermore, the development of new pharmacological strategies is summarized.

Keywords: ocular tumors, epigenetics, retinoblastoma, uveal melanoma, epigenetic drugs

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