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Oral glycopyrrolate for the treatment of chronic severe drooling caused by neurological disorders in children
Authors Evatt M
Published 20 September 2011 Volume 2011:7(1) Pages 543—547
DOI https://doi.org/10.2147/NDT.S14028
Review by Single anonymous peer review
Peer reviewer comments 3
Marian L Evatt
Department of Neurology, Atlanta Veterans Administration Hospital and Emory University School of Medicine, Atlanta, GA, USA
Abstract: Excessive drooling may complicate the care of children with chronic neurological conditions by socially isolating both patients and families and by causing secondary dermatitis and infection. Normal control of saliva requires normal integrity of oral structures, normal oropharyngeal sensation, and motor functioning, as well as normal cognitive awareness and rate of salivary production. Glycopyrrolate is an anticholinergic medication with a quaternary structure that recently received Food and Drug Administration approval to treat sialorrhea due to neurological problems in children ages 3–16 years. This review summarizes the few published studies of safety and efficacy of glycopyrrolate for drooling in children with chronic neurological conditions.
Keywords: drooling, sialorrhoea, sialorrhea, children, glycopyrrolate
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