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Optogenetics: illuminating the neural bases of rodent behavior

Authors Francis TC, Chaudhury D, Lobo MK

Received 17 June 2014

Accepted for publication 3 September 2014

Published 8 December 2014 Volume 2014:6 Pages 33—51

DOI https://doi.org/10.2147/OAAP.S42339

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 5

Editor who approved publication: Dr Peter Koulen

T Chase Francis,1 Dipesh Chaudhury,2 Mary Kay Lobo1

1Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD, USA; 2Department of Biology, New York University Abu Dhabi, Abu Dhabi, United Arab Emirates

Abstract: In vivo optogenetics has provided researchers with the ability to delve deeper into the neural basis of behavior by driving cell-type specific circuit connections within and between brain regions. The diverse toolbox available for circuit- and cell-specific manipulations is ever growing. Using these tools in conjunction with established and novel genetic and behavioral methods, neuroscience research has experienced an explosion in the understanding of the roles of specific cell subtypes in behavior. This review aims to outline recent advances in in vivo optogenetic tools for manipulation of behavior related to movement, pain and sensation, motivation, reward, emotion, learning, sleep, and epilepsy.

Keywords: in vivo optogenetics, behavior, neural circuits, transgenics, viral constructs

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