Back to Journals » Patient Related Outcome Measures » Volume 1

Optimizing use of 5-ASA in the treatment of ulcerative colitis: Focus on patient compliance and adherence

Authors Bernick SJ, Kane S

Published 15 June 2010 Volume 2010:1 Pages 57—63

DOI https://doi.org/10.2147/PROM.S8382

Review by Single-blind

Peer reviewer comments 2


Steven J Bernick1, Sunanda Kane2

1Department of Gastroenterology, Naval Medical Center, San Diego California; 2Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA

Abstract: Ulcerative colitis is a chronic condition that requires long-term treatment. The first-line therapy remains 5-ASA, which is available in a variety of different formulations and dosing schedules. Multiple studies have demonstrated that adherence rates to prescribed 5-ASA products is below what would have been expected with significant consequences for important outcomes. Worse disease outcomes, higher medical costs, and even potentially higher rates of colorectal cancer have been associated with nonadherence. Nonadherence is multifactorial, fluid in nature over time, and dependent on disease activity level. Interventions to improve adherence rates have to be individualized. With the advent of simpler dosing regimens it was assumed that adherence rates would improve, but this has not necessarily been the case. Despite our current knowledge about nonadherence, it remains difficult to manage in the long term.
Keywords: ulcerative colitis, adherence, mesalamine, persistence, compliance

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]