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Optimal management of subfertility in polycystic ovary syndrome

Authors Berger J, Bates Jr GW

Received 18 February 2014

Accepted for publication 2 April 2014

Published 13 June 2014 Volume 2014:6 Pages 613—621

DOI https://doi.org/10.2147/IJWH.S48527

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2


Joshua J Berger, G Wright Bates Jr

University of Alabama at Birmingham, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Birmingham, AL, USA

Abstract: The purpose of this paper is to provide a stepwise approach to treating the infertility/subfertility associated with polycystic ovary syndrome. Defining polycystic ovary syndrome in a patient requires first investigating other possible causes for polycystic ovary morphology, acne, hirsutism, obesity, and the metabolic derangements that often accompany polycystic ovary syndrome. Beginning with lifestyle modification and use of metformin, the progressive inclusion of more intensive therapies for induction of ovulation is described. Second-line treatments are discussed and the new findings from a large multicenter trial are discussed in the context of evidence-based treatment strategies for first-line agents. Finally, monofollicular development as a treatment goal and in vitro fertilization are discussed for those with recalcitrant disease.

Keywords: polycystic ovary syndrome, infertility, metformin, ovarian drilling, ovulation induction, subfertility

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