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Optimal management of multiple sclerosis during pregnancy: current perspectives

Authors Borisow N, Paul F, Dörr J

Received 2 April 2014

Accepted for publication 21 May 2014

Published 5 August 2014 Volume 2014:4 Pages 111—120


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4

Nadja Borisow, Friedemann Paul, Jan Dörr

NeuroCure Clinical Research Center and Clinical and Experimental Research Center for Multiple Sclerosis, Charité – Universitätsmedizin Berlin, Berlin, Germany

Abstract: Multiple sclerosis (MS) is a common inflammatory demyelinating disorder of the central nervous system. It frequently affects females in their reproductive phase of life. Therefore, family planning, pregnancy, and breastfeeding are important issues in the management of MS, particularly with respect to counseling and drug treatment. This paper reviews currently available data on the outcome of pregnancies in MS patients and the influence of pregnancy on the course of the disease. We give an update on the use of various disease-modifying MS drugs during pregnancy and breastfeeding. In addition to established therapies such as interferon-β, glatiramer acetate, natalizumab, and fingolimod, we also discuss the state of knowledge about new agents such as dimethyl fumarate, teriflunomide, and alemtuzumab in the context of pregnancy and breastfeeding.

Keywords: multiple sclerosis, pregnancy, lactation, disease-modifying therapy

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