Back to Journals » Degenerative Neurological and Neuromuscular Disease » Volume 4

Optimal management of multiple sclerosis during pregnancy: current perspectives

Authors Borisow N, Paul F, Dörr J

Received 2 April 2014

Accepted for publication 21 May 2014

Published 5 August 2014 Volume 2014:4 Pages 111—120

DOI https://doi.org/10.2147/DNND.S48618

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4


Nadja Borisow, Friedemann Paul, Jan Dörr

NeuroCure Clinical Research Center and Clinical and Experimental Research Center for Multiple Sclerosis, Charité – Universitätsmedizin Berlin, Berlin, Germany

Abstract: Multiple sclerosis (MS) is a common inflammatory demyelinating disorder of the central nervous system. It frequently affects females in their reproductive phase of life. Therefore, family planning, pregnancy, and breastfeeding are important issues in the management of MS, particularly with respect to counseling and drug treatment. This paper reviews currently available data on the outcome of pregnancies in MS patients and the influence of pregnancy on the course of the disease. We give an update on the use of various disease-modifying MS drugs during pregnancy and breastfeeding. In addition to established therapies such as interferon-β, glatiramer acetate, natalizumab, and fingolimod, we also discuss the state of knowledge about new agents such as dimethyl fumarate, teriflunomide, and alemtuzumab in the context of pregnancy and breastfeeding.

Keywords: multiple sclerosis, pregnancy, lactation, disease-modifying therapy

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]