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Optimal Management of Acute Severe Ulcerative Colitis (ASUC): Challenges and Solutions

Authors Holvoet T, Lobaton T, Hindryckx P

Received 25 July 2020

Accepted for publication 14 December 2020

Published 8 March 2021 Volume 2021:14 Pages 71—81

DOI https://doi.org/10.2147/CEG.S197719

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Professor Andreas M. Kaiser


Tom Holvoet,1,2 Triana Lobaton,2 Pieter Hindryckx2

1Department of Gastroenterology, AZ Nikolaas, Sint-Niklaas, Belgium; 2Department of Gastroenterology, University Hospital Ghent, Ghent, Belgium

Correspondence: Tom Holvoet Email [email protected]

Abstract: Acute severe colitis is a severe complication of ulcerative colitis, affecting approximately 20% of patients. For physicians, it remains a challenging condition to treat. Current treatment algorithms have diminished the mortality associated with acute severe ulcerative colitis (ASUC), but colectomy rates remain high (approximately 30%) despite advances in therapy. Colectomy in ASUC is particularly associated with important postoperative complications and morbidity. In this review, reasons for the inability to improve care and avoid evolution to colectomy for ASUC are explored and solutions that might lead to a better management of the disease are investigated.

Keywords: acute severe colitis, ulcerative colitis, inflammatory bowel disease

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