Opinions of French patients with schizophrenia regarding injectable medication

François Caroli¹, Philippe Raymondet², Isabelle Izard³, Joel Plas⁴, Bérengère Gall⁵, Antonio Delgado^6
1Psychiatry Department, Centre Hospitalier Sainte-Anne, Paris, France; ²Psychiatry Department, CMP Chalucet, Toulon, France; ³Psychiatry Department, CMP Jean Wier, Suresnes, France; ⁴Psychiatry Department, CH Jean Charcot, Vélizy, France; ⁵Opinion and Health Department, BVA Group, Boulogne-Billancourt, France; ⁶Neurosciences Department, Janssen Cilag France, Issy-les-Moulineaux, France

Background: Use of patient-reported outcomes to assess the care of individuals with schizophrenia is increasing. We describe a survey (questionnaire) that evaluates patient opinions on long-acting injectable antipsychotic medication.
Methods: Psychiatrists throughout France selected consenting patients with schizophrenia who had received at least three months' treatment with a long-acting injectable antipsychotic (either typical or atypical) as outpatients to be interviewed by professional interviewers.
Results: A total of 206 patients were interviewed at 19 sites. Ninety-five percent of the patients had been treated with more than one form of dosage; for these individuals, injections were the favored dosage form, being preferred by 47% (compared with 35%, 7%, and 1% expressing a preference for oral tablets, drinkable solutions, and orally disintegrating tablets, respectively, whilst 10% of patients did not express a preference). Over two-thirds of the interviewees (67%) said they felt better having received an injectable treatment than they felt before, and over half the patients (51%) considered injectable therapy to be more effective than other medication. In addition, the majority of the sample (70%) felt better supported in their illness by virtue of regular contact with the doctor or nurse who administered their injection. Patients also reported that injectable treatment could impact positively on their plans and aspirations, with the most frequent consideration for the future relating to finding a job (49% of the sample).
Conclusion: In this survey, patients with schizophrenia had favorable opinions on injectable medication. Ultimately, positive experiences associated with the treatment of schizophrenia in patients receiving long-acting injectable medication may influence the prescription of such therapy by health care providers.

Keywords: schizophrenia, patient opinion, antipsychotic agents, depot preparations, dosage forms, injections