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Ongoing studies of cell-based therapies for articular cartilage defects in Japan

Authors Ogura T, Tsuchiya A, Mizuno S

Received 10 September 2014

Accepted for publication 7 October 2014

Published 18 December 2014 Volume 2015:7 Pages 1—10

DOI https://doi.org/10.2147/ORR.S74068

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Professor Clark Hung


Takahiro Ogura,1 Akihiro Tsuchiya,2 Shuichi Mizuno1

1Department of Orthopedic Surgery, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA; 2Funabashi Orthopaedic Hospital Sports Medicine Center, Funabashi, Chiba, Japan

Abstract: Recently, cell-based therapies have generated great interest in the repair of articular cartilage defects and degeneration. Surgical treatments for these indications have multiple options, including marrow stimulation, osteochondral autograft transplant, and autologous chondrocyte implantation. The autologous chondrocyte implantation technique has been improved using a cell scaffold and other devices. Meanwhile, advanced cell-based therapies, including cultured stem cell treatment, have been studied in clinical trials. Most studies have been designed and authorized by institutional review boards and/or the regulatory agencies of the investigators’ countries. For cellular products in regenerative medicine, regulations of many countries are amenable to expedited approval. This paper aims to provide an update on ongoing and prospective cell-based therapies, focusing on articular cartilage injury at designated institutions authorized by the Japanese Pharmaceutical and Medical Device Agency.

Keywords: autologous chondrocyte implantation, mesenchymal stem cell, knee joint


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