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OnabotulinumtoxinA in the treatment of neurogenic bladder

Authors Gulamhusein, Mangera A

Received 4 July 2012

Accepted for publication 7 August 2012

Published 28 August 2012 Volume 2012:6 Pages 299—306


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Aziz Gulamhusein, Altaf Mangera

Department of Urology Research, Sheffield Teaching Hospitals NHS Trust, Royal Hallamshire Hospital, Sheffield, United Kingdom

Abstract: This review examines the evidence for use of onabotulinumtoxinA in the treatment of neurogenic lower urinary tract dysfunction. Since its first use in 1988 to treat detrusor sphincter dyssynergia, use of botulinum toxin has increased in this group of patients. We discuss the mechanism of action, patient selection, dosing, efficacy, and side effect profile of this now licensed treatment option.

Keywords: neurogenic bladder, botulinum toxin, onabotulinumtoxinA, neurogenic detrusor overactivity, detrusor sphincter dyssynergia

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