Back to Journals » International Journal of Nanomedicine » Volume 6

Oil components modulate the skin delivery of 5-aminolevulinic acid and its ester prodrug from oil-in-water and water-in-oil nanoemulsions

Authors Zhang LW, Al-Suwayeh SA, Hung CF, Chen CC, Fang JY

Published 5 April 2011 Volume 2011:6 Pages 693—704

DOI https://doi.org/10.2147/IJN.S17524

Review by Single-blind

Peer reviewer comments 3

Li-Wen Zhang1, Saleh A Al-Suwayeh2, Chi-Feng Hung3, Chih-Chieh Chen1, Jia-You Fang1,2,4
1Pharmaceutics Laboratory, Graduate Institute of Natural Products, Chang Gung University, Kweishan, Taoyuan, Taiwan; 2Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia; 3School of Medicine, Fu Jen Catholic University, Taipei County, Taiwan; 4Department of Cosmetic Science, Chang Gung Institute of Technology, Kweishan, Taoyuan, Taiwan

Abstract: The study evaluated the potential of nanoemulsions for the topical delivery of 5-aminolevulinic acid (ALA) and methyl ALA (mALA). The drugs were incorporated in oil-in-water (O/W) and water-in-oil (W/O) formulations obtained by using soybean oil or squalene as the oil phase. The droplet size, zeta potential, and environmental polarity of the nanocarriers were assessed as physicochemical properties. The O/W and W/O emulsions showed diameters of 216–256 and 18–125 nm, which, respectively, were within the range of submicron- and nano-sized dispersions. In vitro diffusion experiments using Franz-type cells and porcine skin were performed. Nude mice were used, and skin fluorescence derived from protoporphyrin IX was documented by confocal laser scanning microscopy (CLSM). The loading of ALA or mALA into the emulsions resulted in slower release across cellulose membranes. The release rate and skin flux of topical drug application were adjusted by changing the type of nanocarrier, the soybean oil O/W systems showing the highest skin permeation. This formulation increased ALA flux via porcine skin to 180 nmol/cm2/h, which was 2.6-fold that of the aqueous control. The CLSM results showed that soybean oil systems promoted mALA permeation to deeper layers of the skin from ~100 µm to ~140 µm, which would be beneficial for treating subepidermal and subcutaneous lesions. Drug permeation from W/O systems did not surpass that from the aqueous solution. An in vivo dermal irritation test indicated that the emulsions were safe for topical administration of ALA and mALA.

Keywords: nanoemulsions, 5-aminolevulinic acid, methyl 5-aminolevulinic acid, skin permeation, soybean oil, squalene

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]

 

Other articles by this author:

Anti-MRSA malleable liposomes carrying chloramphenicol for ameliorating hair follicle targeting

Hsu C, Yang S, Sung CT, Weng Y, Fang J

International Journal of Nanomedicine 2017, 12:8227-8238

Published Date: 10 November 2017

Squarticles as the nanoantidotes to sequester the overdosed antidepressant for detoxification

Chen CH, Huang TH, Elzoghby AO, Wang PW, Chang CW, Fang JY

International Journal of Nanomedicine 2017, 12:8071-8083

Published Date: 1 November 2017

Self-nanoemulsifying drug delivery systems ameliorate the oral delivery of silymarin in rats with Roux-en-Y gastric bypass surgery

Chen CH, Chang CC, Shih TH, Aljuffali IA, Yeh TS, Fang JY

International Journal of Nanomedicine 2015, 10:2403-2416

Published Date: 25 March 2015

Theranostic liposomes loaded with quantum dots and apomorphine for brain targeting and bioimaging

Wen CJ, Zhang LW, Al-Suwayeh SA, Yen TC, Fang JY

International Journal of Nanomedicine 2012, 7:1599-1611

Published Date: 26 March 2012

Combination of calcipotriol and methotrexate in nanostructured lipid carriers for topical delivery

Yin-Ku Lin, Zih-Rou Huang, Rou-Zi Zhuo, et al

International Journal of Nanomedicine 2010, 5:117-128

Published Date: 25 February 2010

Readers of this article also read:

Green synthesis of water-soluble nontoxic polymeric nanocomposites containing silver nanoparticles

Prozorova GF, Pozdnyakov AS, Kuznetsova NP, Korzhova SA, Emel’yanov AI, Ermakova TG, Fadeeva TV, Sosedova LM

International Journal of Nanomedicine 2014, 9:1883-1889

Published Date: 16 April 2014

Methacrylic-based nanogels for the pH-sensitive delivery of 5-Fluorouracil in the colon

Ashwanikumar N, Kumar NA, Nair SA, Kumar GS

International Journal of Nanomedicine 2012, 7:5769-5779

Published Date: 15 November 2012

A novel preparation method for silicone oil nanoemulsions and its application for coating hair with silicone

Hu Z, Liao M, Chen Y, Cai Y, Meng L, Liu Y, Lv N, Liu Z, Yuan W

International Journal of Nanomedicine 2012, 7:5719-5724

Published Date: 12 November 2012

Cross-linked acrylic hydrogel for the controlled delivery of hydrophobic drugs in cancer therapy

Deepa G, Thulasidasan AK, Anto RJ, Pillai JJ, Kumar GS

International Journal of Nanomedicine 2012, 7:4077-4088

Published Date: 27 July 2012

Servant leadership: a case study of a Canadian health care innovator

Vanderpyl TH

Journal of Healthcare Leadership 2012, 4:9-16

Published Date: 16 February 2012

Crystallization after intravitreal ganciclovir injection

Pitipol Choopong, Nattaporn Tesavibul, Nattawut Rodanant

Clinical Ophthalmology 2010, 4:709-711

Published Date: 14 July 2010

Pharmacokinetics and tolerance study of intravitreal injection of dexamethasone-loaded nanoparticles in rabbits

Linhua Zhang, Yue Li, Chao Zhang, et al

International Journal of Nanomedicine 2009, 4:175-183

Published Date: 4 September 2009