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Ocular manifestations of graft-versus-host disease: 10 years’ experience

Authors Lin X, Cavanagh HD

Received 16 March 2015

Accepted for publication 29 April 2015

Published 3 July 2015 Volume 2015:9 Pages 1209—1213

DOI https://doi.org/10.2147/OPTH.S84704

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4

Editor who approved publication: Dr Scott Fraser


Xihui Lin, Harrison Dwight Cavanagh

Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX, USA

Purpose: To evaluate the ocular presentation, treatment, and clinical course of graft-versus-host disease (GVHD).
Design: Retrospective case series.
Participants: Two hundred and forty-nine patients with systemic GVHD were included in the study.
Methods: Ocular and systemic data were collected from 2003 to 2013.
Main outcome measures: Mortality, visual acuity, and response of ocular symptoms.
Results: Sixty-four patients had ocular manifestations (25.7%). At presentation, the mean age was 44.5 years and mean latency was 16.4 months. The most common presentations were keratoconjunctivitis sicca, cataract, blepharitis, ocular hypertension, and filamentary keratitis. Visual acuity at presentation was 20/49; at the worst point in the disease was 20/115; and at most recent visit was 20/63. When topical anti-inflammatory drops were used in addition to tears, 54.3% of patients’ ocular symptoms stabilized. When autologous serum was used in addition, 80% stabilized. The overall 10-year mortality of GVHD was 29.7%. For those with ocular involvement, it was 21.9%.
Conclusion: Systemic GVHD has a high mortality rate, but ocular involvement does not suggest a worse prognosis. The main ocular presentations were keratoconjunctivitis sicca, cataracts, and ocular hypertension. Dry eyes in this population were very severe with overall worsening in visual acuity. However, with a step-wise approach involving topical anti-inflammatory medications and autologous serum tears, ocular symptoms do improve. It is important to monitor these patients closely, as they are prone to serious ocular complications such as corneal perforation and endophthalmitis.

Keywords: dry eye, keratitis, corneal ulceration

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