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Objective and subjective in vivo comparison of two emollient products

Authors Djokic-Gallagher, Rosher, Walker, Hart

Received 5 April 2012

Accepted for publication 13 May 2012

Published 8 August 2012 Volume 2012:5 Pages 85—91


Review by Single anonymous peer review

Peer reviewer comments 2

Jasmina Djokic-Gallagher,1 Phil Rosher,1 Jennine Walker,1 Valerie Hart2

1Research and Development Department, Dermal Laboratories Ltd, Hitchin, 2Reading Scientific Services Ltd, Reading Science Centre, Whiteknights Campus, University of Reading, Reading, UK

Background: Few studies have directly compared the effectiveness of different emollients in vivo, and the important matter of patient preference is generally overlooked.
Methods: We report the results of an assessor-blinded, bilateral, concurrent comparison of two emollient pharmaceutical presentations, ie, Doublebase gel (DB) and Aqueous cream BP (AC), applied by 20 participants three times daily for 7 consecutive days. The primary efficacy endpoint was cumulative improvement in skin hydration measured by corneometry on days 1, 3, and 5 immediately before the first application and approximately 2 hours after the third application of the day. Secondary endpoints were investigator assessment of skin condition at these time points and participant assessment of product acceptability at the end of the study.
Results: Both products increased skin hydration, but the effect of AC was relatively modest, with morning values readily returning to pretreatment levels. Hydration levels were higher for DB gel, maintained at all time points, and showed stepwise, cumulative increases over the 7 days of use. Overall patient satisfaction scores were higher for DB gel, and especially for “consistency,” “ease of use,” and “ease of absorption into the skin.” Eighty-five percent of participants expressed a desire to use DB gel again as compared with 40% for AC.

Keywords: Doublebase, Aqueous cream, hydration, emollient, comparison

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