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Novel tumor markers in the serum of testicular germ cell cancer patients: a review

Authors Syring I, Müller SC, Ellinger J

Received 16 April 2014

Accepted for publication 29 May 2014

Published 9 September 2014 Volume 2014:4 Pages 133—137


Checked for plagiarism Yes

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Peer reviewer comments 4

Isabella Syring, Stefan C Müller, Jörg Ellinger

Department for Urology and Pediatric Urology, University Hospital Bonn, Bonn, Germany

Abstract: Serum tumor markers have an important role in the management of patients with testicular cancer. They are useful for diagnosis, staging and risk assessment, follow-up, evaluation of response, and early detection of relapse. Alpha-fetoprotein, human chorionic gonadotropin, and lactate dehydrogenase are established serum markers in testicular cancer, but they have a limited sensitivity. Ongoing research may lead to the identification of novel biomarkers. Therefore, we review the experimental analyses for nucleic acids, circulating tumor cells, and proteins as potential biomarkers in the serum of testicular germ cell cancer patients.

Keywords: biomarker, serum, testicular germ cell cancer

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