Back to Archived Journals » Current Biomarker Findings » Volume 4

Novel tumor markers in the serum of testicular germ cell cancer patients: a review

Authors Syring I, Müller SC, Ellinger J

Received 16 April 2014

Accepted for publication 29 May 2014

Published 9 September 2014 Volume 2014:4 Pages 133—137

DOI https://doi.org/10.2147/CBF.S66068

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4


Isabella Syring, Stefan C Müller, Jörg Ellinger

Department for Urology and Pediatric Urology, University Hospital Bonn, Bonn, Germany


Abstract: Serum tumor markers have an important role in the management of patients with testicular cancer. They are useful for diagnosis, staging and risk assessment, follow-up, evaluation of response, and early detection of relapse. Alpha-fetoprotein, human chorionic gonadotropin, and lactate dehydrogenase are established serum markers in testicular cancer, but they have a limited sensitivity. Ongoing research may lead to the identification of novel biomarkers. Therefore, we review the experimental analyses for nucleic acids, circulating tumor cells, and proteins as potential biomarkers in the serum of testicular germ cell cancer patients.

Keywords: biomarker, serum, testicular germ cell cancer

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]