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Novel flower-shaped albumin particles as controlled-release carriers for drugs to penetrate the round-window membrane

Authors Yu Z, Yu M, Zhou Z, Zhang Z, Du B, Xiong Q

Received 27 December 2013

Accepted for publication 10 March 2014

Published 1 July 2014 Volume 2014:9(1) Pages 3193—3201

DOI https://doi.org/10.2147/IJN.S59807

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Zhan Yu,1,* Min Yu,2,* Zhimin Zhou,3 Zhibao Zhang,3 Bo Du,3 Qingqing Xiong3

1Second Artillery General Hospital, Beijing, 2Department of Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, College of Basic Medicine, China Medical University, Shenyang, 3Institute of Biomedical Engineering, Chinese Academy of Medical Sciences, Peking Union Medical College, Key Laboratory of Biomedical Material
of Tianjin, Tianjin, People’s Republic of China

*These authors contributed equallyto this work

Abstract: Controlled-release carriers for local drug delivery have attracted increasing attention for inner-ear treatment recently. In this paper, flower-shaped bovine serum albumin (FBSA) particles were prepared by a modified desolvation method followed by glutaraldehyde or heat denaturation. The size of the FBSA particles varied from 10 µm to 100 µm, and most were 50–80 µm. Heat-denatured FBSA particles have good cytocompatibility with a prolonged survival time for L929 cells. The FBSA particles were utilized as carriers to investigate the release behaviors of the model drug – rhodamine B. Rhodamine B showed a sustained-release effect and penetrated the round-window membrane of guinea pigs. We also confirmed the attachment of FBSA particles onto the round-window membrane by microscopy. The FBSA particles, with good biocompatibility, drug-loading capacity, adhesive capability, and biodegradability, may have potential applications in the field of local drug delivery for inner-ear disease treatment.

Keywords: bovine serum albumin (BSA), controlled release, local delivery, round-window membrane

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