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Novel diagnostic approaches and biological therapeutics for intrinsic asthma

Authors Vennera MDC, Picado C

Received 17 March 2014

Accepted for publication 3 June 2014

Published 8 July 2014 Volume 2014:7 Pages 365—371


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 4

María del Carmen Vennera,1–3 César Picado1–3

1Department of Pneumology and Respiratory Allergy, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain; 2Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; 3Centro de Investigaciones Biomédicas en Red de Enfermedades Respiratorias (CIBERES), Spain

Abstract: Intrinsic asthma has been considered as a specific disease entity for a long time, although many controversies have emerged in relation to this concept. Of note, not finding specific allergen sensitization in an asthmatic patient neither excludes an allergic component nor the essential role that immunoglobulin E may play in asthma. The diagnostic approach should be similar in any patient suspected to have asthma. The atopic status is one among many other questions. Omalizumab, the only monoclonal anti-immunoglobulin E antibody commercialized for asthma, should be tried in patients with uncontrolled severe asthma independent of their atopic status.

Keywords: nonatopic asthma, immunoglobulin E, omalizumab

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