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Novel Bruton's tyrosine kinase inhibitors currently in development

Authors D'Cruz OJ, Uckun F

Received 19 December 2012

Accepted for publication 4 February 2013

Published 6 March 2013 Volume 2013:6 Pages 161—176

DOI https://doi.org/10.2147/OTT.S33732

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4


Osmond J D'Cruz,1 Fatih M Uckun1,2

1Children's Center for Cancer and Blood Diseases, Children's Hospital Los Angeles, Los Angeles, CA, USA; 2Department of Pediatrics, University of Southern California, Los Angeles, CA, USA

Abstract: Bruton's tyrosine kinase (Btk) is intimately involved in multiple signal-transduction pathways regulating survival, activation, proliferation, and differentiation of B-lineage lymphoid cells. Btk is overexpressed and constitutively active in several B-lineage lymphoid malignancies. Btk has emerged as a new antiapoptotic molecular target for treatment of B-lineage leukemias and lymphomas. Preclinical and early clinical results indicate that Btk inhibitors may be useful in the treatment of leukemias and lymphomas.

Keywords: tyrosine kinase, personalized therapy, kinase inhibitors, Btk, leukemia, lymphoma

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