Back to Archived Journals » International Journal of Interferon, Cytokine and Mediator Research » Volume 3

Nonsteroidal anti-inflammatory drugs: prostaglandins, indications, and side effects

Authors Pountos I, Georgouli T, Bird H, Giannoudis PV

Published 28 January 2011 Volume 2011:3 Pages 19—27

DOI https://doi.org/10.2147/IJICMR.S10200

Review by Single-blind

Peer reviewer comments 6


Ippokratis Pountos1, Theodora Georgouli1, Howard Bird2, Peter V Giannoudis1
1Academic Department of Trauma and Orthopaedics, School of Medicine, 2Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds, Leeds, UK

Abstract: For centuries, nonsteroidal anti-inflammatory drugs (NSAIDs) have been part of our clinical practice. They started out as drugs with anti-inflammatory and analgesic action, and gradually their use has been expanded to new therapeutic targets, some of which are unrelated to their primary mode of action. Today, our armamentarium includes a large range of compounds, attesting to their utility in the treatment of clinical pathologies ranging from pain and inflammation to prevention and treatment of cancer. On the other hand, although NSAIDs share many common properties, their use poses risks, and physicians should be cognizant of their subtle differences and potential complications. In this context, this review article presents insight into NSAIDs’ pathophysiology and mode of action in the clinical setting, their indications, and their potential side effects.

Keywords: nonsteroidal anti-inflammatory drugs, prostaglandins, COX

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]