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Non-O1, Non-O139 Vibrio cholerae (NOVC) Bacteremia: Case Report and Literature Review, 2015–2019

Authors Zhang X, Lu Y, Qian H, Liu G, Mei Y, Jin F, Xia W, Ni F

Received 13 January 2020

Accepted for publication 22 March 2020

Published 7 April 2020 Volume 2020:13 Pages 1009—1016


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Dr Eric Nulens

Xiaohui Zhang,1,2,* Yanfei Lu,1,2,* Huimin Qian,3 Genyan Liu,1,2 Yaning Mei,1,2 Fei Jin,1,2 Wenying Xia,1,2 Fang Ni1,2

1Department of Laboratory Medicine, Jiangsu Province Hospital and Nanjing Medical University First Affiliated Hospital, Nanjing, People’s Republic of China; 2National Key Clinical Department of Laboratory Medicine, Nanjing, People’s Republic of China; 3Key Laboratory of Enteric Pathogenic Microbiology of Ministry of Health, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, People’s Republic of China

*These authors contributed equally to this work

Correspondence: Wenying Xia; Fang Ni
Department of Laboratory Medicine, Jiangsu Province Hospital, Guangzhou Street No. 300, 210029, People’s Republic of China
Tel +8625-6830-6287
Fax +8625-8372-4440

Abstract: Non-O1, non-O139 Vibrio cholerae (NOVC) does not agglutinate with O1 and O139 antisera and can cause intestinal and extraintestinal infections in immunocompromised individuals. NOVC bacteremia has the highest mortality among NOVC infections, and the number of reports has increased in recent years. Nevertheless, some clinicians are poorly informed about this disease. Herein, we describe a documented case of NOVC bacteremia in a male patient with impaired liver function. Blood cultures revealed the presence of V. cholerae, but this strain showed self-coagulation on the serum agglutination test. To our knowledge, this phenomenon is unreported among cases of NOVC infections. This pathogen was finally confirmed as NOVC via PCR. Because the patient worked as a garbage transporter, he was likely infected after contact with contaminated water through a foot wound. The patient developed septic shock shortly after admission and ultimately died from the illness. This paper reviews 23 cases of NOVC bacteremia from 2015 to  2019. To improve the accuracy of identifying NOVC and analyze its virulence factors, relevant detection methods were reviewed and analyzed.

Keywords: bacteremia, non-O1/non-O139 Vibrio cholerae, V. cholerae, virulence factors

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