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Non-invasive imaging of microcirculation: a technology review

Authors Eriksson S, Nilsson J, Sturesson C

Received 10 August 2014

Accepted for publication 23 October 2014

Published 9 December 2014 Volume 2014:7 Pages 445—452

DOI https://doi.org/10.2147/MDER.S51426

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Dr Scott Fraser


Sam Eriksson,1,2 Jan Nilsson,1,2 Christian Sturesson1,2

1Department of Surgery, Clinical Sciences Lund, Lund University, 2Skåne University Hospital, Lund, Sweden

Abstract: Microcirculation plays a crucial role in physiological processes of tissue oxygenation and nutritional exchange. Measurement of microcirculation can be applied on many organs in various pathologies. In this paper we aim to review the technique of non-invasive methods for imaging of the microcirculation. Methods covered are: videomicroscopy techniques, laser Doppler perfusion imaging, and laser speckle contrast imaging. Videomicroscopy techniques, such as orthogonal polarization spectral imaging and sidestream dark-field imaging, provide a plentitude of information and offer direct visualization of the microcirculation but have the major drawback that they may give pressure artifacts. Both laser Doppler perfusion imaging and laser speckle contrast imaging allow non-contact measurements but have the disadvantage of their sensitivity to motion artifacts and that they are confined to relative measurement comparisons. Ideal would be a non-contact videomicroscopy method with fully automatic analysis software.

Keywords: laser speckle contrast imaging, sidestream dark-field, orthogonal polarization spectral imaging, laser Doppler imaging

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