Back to Journals » OncoTargets and Therapy » Volume 11

Nomogram for predicting survival in patients with pancreatic cancer

Authors Song W, Miao DL, Chen L

Received 19 October 2017

Accepted for publication 7 December 2017

Published 24 January 2018 Volume 2018:11 Pages 539—545

DOI https://doi.org/10.2147/OTT.S154599

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Manfred Beleut

Peer reviewer comments 2

Editor who approved publication: Dr William Cho


 
Wei Song, Dong-Liu Miao, Lei Chen

Department of Intervention and Vascular Surgery, Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou Cancer Medical Center, Suzhou, People’s Republic of China

Background: The purpose of this study was to develop a nomogram to predict cancer-specific survival (CSS) in pancreatic cancer (PC).
Patients and methods: We used the Surveillance, Epidemiology, and End Results (SEER) database to analyze 53,028 patients diagnosed with PC from 2004 to 2014 and randomly divided them into the training (n=26,583) cohort and validation (n=26,445) cohort. Univariate and multivariate analyses were used to select independent prognostic factors. We used significant prognostic factors for constructing a nomogram based on Cox regression analyses. Validation of the nomogram was assessed by discrimination and calibration.
Results: According to the multivariate models of training cohort, a nomogram that combined age, race, tumor location, marital status, tumor size, TNM stage, tumor grade, and surgery was constructed for predicting CSS. The internally validated and externally validated C-indexes were 0.741 and 0.734, respectively. The calibration curves showed that the nomogram was able to predict 1-, 3-, and 5-year CSS accurately.
Conclusion: A nomogram effectively predicts survival in patients with PC. This prognostic model may be considered for use in clinical practice.
 
Keywords: pancreatic cancer, nomogram, SEER, cancer-specific survival, prognosis

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]