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No association between the presence of periodontal disease and poor IVF outcomes: a pilot study

Authors Khalife D, Khalil A, Itani MN, Khalifeh F, Faour S, Salame A, Ghazeeri G

Received 18 January 2019

Accepted for publication 22 April 2019

Published 10 June 2019 Volume 2019:11 Pages 363—370

DOI https://doi.org/10.2147/IJWH.S202135

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Professor Elie Al-Chaer


Dalia Khalife,1 Ali Khalil,1 Mohamad N Itani,2 Fatin Khalifeh,1 Sara Faour,1 Anastasia Salame,1 Ghina Ghazeeri1

1Department of Obstetrics & Gynecology, American University of Beirut Medical Center, Beirut, Lebanon; 2Department of Dentistry, American University of Beirut Medical Center, Beirut, Lebanon

Background: Periodontal disease can lead to bacteremia with release of cytokines, affecting implantation in women trying to conceive through in vitro fertilization (IVF). A potential association between maternal periodontal disease and poor IVF outcomes has been described.
Objective: The aim of the study is to assess whether pre-existing periodontal disease has any effect on IVF parameters.
Method: A pilot study composed of 34 women was conducted at a tertiary care center. Prior to IVF, dental examination, IVF parameters were collected.
Results: Thirty-four women participated in the study. The outcomes of 28 women (82.3%) were analyzed. Out of the 28 patients, 17 patients had a positive pregnancy test (60.7%) with a total of 13 live births (46.4%) and 4 pregnancy losses (14.3%). Plaque and bleeding index scores were both lower in patients who achieved pregnancy after IVF yet did not reach statistical significance (p=0.309 and 0.422). Comparison of mean values for the different infertility parameters showed no significant differences among women with different IVF outcomes (p>0.05). Different degrees of inflammation of the gingiva did not have an effect on the different clinical parameters and the live birth rates.
Conclusion: The evidence provided by the present study does not support the hypothesis. Addressing the status of oral health before any infertility treatment remains to be elucidated.

Keywords: periodontal disease, in vitro fertilization, infertility, inflammation, live birth

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