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Night-shift work and risk of breast cancer in Korean women

Authors Pham TT, Hwang M, Lee ES, Kong SY, Jung SY, Lee S, Kim J, Ha M, Kim SY, Park B

Received 25 December 2018

Accepted for publication 26 July 2019

Published 21 August 2019 Volume 2019:11 Pages 743—751

DOI https://doi.org/10.2147/CLEP.S199521

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Professor Vera Ehrenstein


Thu-Thi Pham,1 Minji Hwang,2 Eun-Sook Lee,1,3,4 Sun-Young Kong,1,3,4 So-Youn Jung,3,4 Seeyoun Lee,4 Jeongseon Kim,1,3 Mina Ha,5 Sun-Young Kim,1 Boyoung Park2

1National Cancer Center Graduate School of Cancer Science and Policy, Goyang, Republic of Korea; 2Department of Medicine, Hanyang University College of Medicine, Seoul, Republic of Korea; 3Research Institute, National Cancer Center, Goyang, Republic of Korea; 4Hospital, National Cancer Center, Goyang, Republic of Korea; 5Dankook University College of Medicine, Cheonan, Republic of Korea

Correspondence: Boyoung Park
Department of Medicine, Hanyang University College of Medicine, 222 Wangsimni-ro, Seongdong-gu, Seoul 04763, Republic of Korea
Tel +82 22 220 0682
Fax +82 312 220 0699
Email hayejine@hanmail.net

Purpose: This study evaluated the association between night-shift work (NSW) and breast cancer risk as well as subtypes of breast cancer in Korean women.
Patients and methods: The study population included 1721 female breast cancer cases and 1721 female controls matched by age. The subtypes of breast cancer were determined based on estrogen, progesterone, and human epidermal growth factor receptor 2 statuses by reviewing pathology reports. Odds ratios (ORs) for NSW experience, age at commencement of NSW, frequency, and duration were estimated using conditional logistic regression and were adjusted for confounders such as parity and socioeconomic status–related factors.
Results: Among 1721 pairs, 10.58% of cases and 9.59% of controls had ever engaged in NSW. NSW was not associated with breast cancer risk in terms of ever having night-shift exposure (adjusted OR was 1.11, 95% confidence interval [CI] =0.89–1.40), duration, frequency, or cumulative working time. The OR for >10 years of lifetime duration of NSW was 1.55 (95% CI 0.89–2.69, P=0.124). In addition, the OR for >35,000 hrs for cumulative frequency of night work was OR=1.42 (95% CI=0.73–2.74, P=0.304). There was no heterogeneity in ORs of ever having NSW and cumulative duration of NSW between four subtypes of breast cancer.
Conclusion: NSW including long-term and heavy working exposure was not associated with breast cancer risk.

Keywords: night-shift work, breast cancer, hormone receptor, estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2

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