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Newcastle disease virus, rituximab, and doxorubicin combination as anti-hematological malignancy therapy

Authors Al-Shammari A, Rameez H, Al-Taee M

Received 27 August 2015

Accepted for publication 23 December 2015

Published 20 April 2016 Volume 2016:5 Pages 27—34

DOI https://doi.org/10.2147/OV.S95250

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Ram Prasad

Peer reviewer comments 2

Editor who approved publication: Dr Faris Farassati


Video abstract presented by Dr Ahmed Majeed Al-Shammari.

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Ahmed Majeed Al-Shammari,1 Huda Rameez,2 Maha F Al-Taee2

1Department of Experimental Therapy, Iraqi Center for Cancer and Medical Genetic Research, Mustansiriyah University, 2Department of Biotechnology, College of Science, Baghdad University, Baghdad, Iraq

Abstract: Hematological malignancies are important diseases that need more powerful therapeutics. Even with current targeting therapies, such as rituximab and other chemotherapeutic agents, there is a need to develop new treatment strategies. Combination therapy seems the best option to target the tumor cells by different mechanisms. Virotherapy is a very promising treatment modality, as it is selective, safe, and causes cancer destruction. The Iraqi strain of Newcastle disease virus (NDV) has proved to be effective both in vitro and in vivo. In the current work, we tested its ability on anti-hematological tumors and enhanced current treatments with combination therapy, and studied this combination using Chou–Talalay analysis. p53 concentration was measured to evaluate the mechanism of this proposed synergism. The results showed that NDV was synergistic with doxorubicin in low doses on plasmacytoma cells, with no involvement of p53 pathways, but involved p53 when the combination was used on non-Hodgkin lymphoma cells. NDV in combination with rituximab showed enhanced cytotoxicity that was p53-independent. In conclusion, this work proposes a novel combination modality for treatment of some hematological malignancies.

Keywords: oncolytic viruses, virotherapy, combination therapy

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