Back to Journals » International Journal of Chronic Obstructive Pulmonary Disease » Volume 6

New therapeutic options in the management of COPD – focus on roflumilast

Authors Antoniu S

Published 17 February 2011 Volume 2011:6 Pages 147—155

DOI https://doi.org/10.2147/COPD.S7336

Review by Single-blind

Peer reviewer comments 2

Sabina Antonela Antoniu
University of Medicine and Pharmacy, Pulmonary Disease Division, Pulmonary Disease University Hospital, Iasi, Romania

Abstract: In chronic obstructive pulmonary disease (COPD) the inflammation occurring in the airways and in other lung tissues is complex and is orchestrated by various mediators including the isoenzyme 4 of the phosphodiesterases family (PDE4), which contributes to bronchoconstriction and inflammation. Various PDE4 inhibitors have been evaluated as potential therapies in asthma or COPD but among these only roflumilast have been authorized in Europe to be used in patients with severe COPD as an add-on to the bronchodilator therapy. This review discusses the existing preclinical and clinical data supporting the use of roflumilast for this therapeutic indication and tackles some of the pending issues related to PDE4 in general and to roflumilast in particular.

Keywords: COPD, roflumilast, PDE4, efficacy, safety

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]

 

Readers of this article also read:

Disability related to COPD tool (DIRECT): towards an assessment of COPD-related disability in routine practice

Aguilaniu B, Gonzalez-Bermejo J, Regnault A, Dias Barbosa C, Arnould B, Mueser M, Granet G, Bonnefoy M, Similowski T

International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:387-398

Published Date: 5 July 2011

Optimizing management of chronic obstructive pulmonary disease in the upcoming decade

Richard Russell, Antonio Anzueto, Idelle Weisman

International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:47-61

Published Date: 10 January 2011

Efficacy and safety of tiotropium Respimat® SMI in COPD in two 1-year randomized studies

Eric Bateman, Dave Singh, David Smith, et al

International Journal of Chronic Obstructive Pulmonary Disease 2010, 5:197-208

Published Date: 9 June 2010