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New-generation filler based on cross-linked carboxymethylcellulose: study of 350 patients with 3-year follow-up

Authors Leonardis M, Palange A

Received 16 September 2014

Accepted for publication 12 November 2014

Published 6 January 2015 Volume 2015:10 Pages 147—155

DOI https://doi.org/10.2147/CIA.S74445

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Dr Richard Walker

Mauro Leonardis,1 Andrea Palange2

1Department of Plastic Surgery, Salvator Mundi International Hospital, 2Department of Aesthetic Medicine, Fisiobios Clinic, Rome, Italy


Purpose: In recent years there has been a growing interest in nonsurgical procedures for facial rejuvenation. Hyaluronic acid is currently the most widely used dermal filler for the treatment of facial wrinkles. However, new products with interesting features are being introduced into the market. Cross-linked carboxymethylcellulose is one of these and represents a new alternative for the correction of wrinkles and facial defects.
Patients and methods: The retrospective, multicenter, open-label study on nasolabial folds reported here was carried out between January 2010 and April 2014 on 350 subjects between 22 and 67 years of age for a 36-month follow-up period in order to consistently and extensively assess the safety and performance of this treatment.
Results: The study revealed effective and durable correction of nasolabial wrinkles for periods of 9–12 months. Product reapplication over a 36-month period did not lead to an increase in adverse effects, which always remained rare and of little clinical significance, usually consisting of bruising and redness.
Conclusion: Cross-linked carboxymethyl cellulose has been shown to be a safe and effective alternative to the resorbable products currently on the market.

Keywords: dermal fillers, nasolabial fold, hyaluronic acids, facial aging, patient satisfaction

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Other article by this author:

Use of cross-linked carboxymethyl cellulose for soft-tissue augmentation: preliminary clinical studies

Mauro Leonardis, Andrea Palange, Rodrigo FV Dornelles, et al

Clinical Interventions in Aging 2010, 5:317-322

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