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New form of administering chlorhexidine for treatment of denture-induced stomatitis

Authors Ryalat ST, Darwish R, Amin W

Published 14 June 2011 Volume 2011:7 Pages 219—225


Review by Single anonymous peer review

Peer reviewer comments 3

Soukaina Ryalat, Rula Darwish, Wala Amin
Department of Oral Surgery, Jordan University, Amman, Jordan

Background: The purpose of this study was to evaluate the release of chlorhexidine as an antifungal drug from doped self-cured poly (methyl methacrylate) (PMMA) acrylic resin and the effect of the drug released on the growth of Candida albicans.
Methods: Release of chlorhexidine was evaluated using liquid chromatography, and the effect of the drug on the growth of C. albicans was investigated microbiologically using a “well” technique on Saboraud culture medium inoculated with a resistant strain of C. albicans.
Results: Chlorhexidine leached steadily out of the acrylic resin into distilled water at mouth temperature, and the sustained drug release continued throughout the 28-day test period. The drug released also demonstrated antifungal activity against the resistant strain of C. albicans.
Conclusion: The findings of this study support the use of chlorhexidine-impregnated self-cured PMMA chair-side resin as a new dosage form for the treatment of denture-induced stomatitis.

Keywords: chlorhexidine, poly (methyl methacrylate), eluates, antifungal drug, denture stomatitis, Candida albicans

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