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New developments in the treatment of basal cell carcinoma: update on current and emerging treatment options with a focus on vismodegib

Authors Koelblinger P, Lang R

Received 3 July 2018

Accepted for publication 22 October 2018

Published 23 November 2018 Volume 2018:11 Pages 8327—8340


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Dr Yao Dai

Peter Koelblinger, Roland Lang,

Department of Dermatology, Paracelsus Medical University, Salzburg, Austria

Abstract: Basal cell carcinoma (BCC) is the most common form of skin cancer worldwide. Although most BCCs can be treated by relatively simple surgical or nonsurgical methods, some patients with BCC may eventually develop advanced disease which can either be locally destructive or even include metastatic spread. The present review summarizes the current literature on the treatment of both early and advanced BCC with a focus on the hedgehog inhibitor vismodegib which has become an integral part of the management of patients with advanced BCC since its regulatory approval in 2012.

Keywords: basal cell carcinoma, treatment, PTCH1, hedgehog inhibitor

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