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New approaches for the management of bipolar disorder: role of sublingual asenapine in the treatment of mania

Authors Warren CG, Dubovsky SL

Received 11 March 2013

Accepted for publication 18 April 2013

Published 24 May 2013 Volume 2013:9 Pages 753—758

DOI https://doi.org/10.2147/NDT.S16078

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 5

Calvert G Warren,1 Steven L Dubovsky1,2

1Department of Psychiatry, State University of New York at Buffalo, Buffalo, NY, USA; 2Departments of Psychiatry and Medicine, University of Colorado, Boulder, CO, USA

Abstract: Bipolar disorder is a prevalent disorder that tends to become progressive without treatment and with inadequate treatment. Second generation (atypical) antipsychotic drugs have increasingly been used as adjunctive treatment or monotherapy for mania, but they have the potential for significant adverse effects and their role in maintenance treatment remains unclear. Asenapine is a new atypical antipsychotic medication formulated in a sublingual preparation that has been studied for mania but not maintenance therapy. Evidence indicating efficacy, adverse effects, and potential benefits and drawbacks of using asenapine in the treatment of bipolar disorder based on currently available published data are summarized.

Keywords: bipolar disorder, antipsychotic drug, mania, maintenance, sublingual

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