Back to Journals » Vascular Health and Risk Management » Volume 9

Neutrophil/lymphocyte ratio in patients with atrial septal aneurysm

Authors Demir M, Demir C

Received 21 May 2013

Accepted for publication 19 June 2013

Published 19 July 2013 Volume 2013:9 Pages 365—368


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Mehmet Demir,1 Canan Demir2

1Department of Cardiology, Bursa Yüksek İhtisas Education and Research Hospital, Bursa, Turkey; 2Department of Infectious Diseases, Bursa Şevket Yilmaz Education and Research Hospital, Bursa, Turkey

Background: Systemic thromboembolism is a serious, major complication in patients with an atrial septal aneurysm (ASA). Paroxysmal atrial fibrillation (AF) is more common in patients with ASA than in the normal population. Neutrophil/lymphocyte ratio (NLR) has been associated with postoperative AF development in patients who have undergone cardiac surgery. This study investigated NLR in a group of ASA patients compared with a control group of healthy volunteers.
Patients and methods: The study group consisted of 40 patients with ASA; the control group consisted of 30 age-, sex-, and body mass index-matched healthy volunteers. All patients and control subjects underwent echocardiographic examination. No patient had a recent history of an acute infection or an inflammatory disease. Baseline NLR was measured by dividing neutrophil count by lymphocyte count.
Results: No statistically significant difference was found between the two groups in terms of basic characteristics. Mean NLR was significantly higher among persons with ASA compared with controls (3.4 ± 1.5 vs 1.6 ± 0.97, P < 0.001).
Conclusion: Our results suggest that a higher NLR, an emerging marker of inflammation, has a positive correlation with ASA. The measurement of NLR may be used to indicate an increased risk of arrhythmia, such as AF, in ASA patients.

Keywords: neutrophil-lymphocyte ratio, inflammation, arrhythmia

A Letter to the Editor has been received and published for this article.

Creative Commons License © 2013 The Author(s). This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.