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Neutrophil/lymphocyte ratio in patients with atrial septal aneurysm
Received 21 May 2013
Accepted for publication 19 June 2013
Published 19 July 2013 Volume 2013:9 Pages 365—368
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Mehmet Demir,1 Canan Demir2
1Department of Cardiology, Bursa Yüksek İhtisas Education and Research Hospital, Bursa, Turkey; 2Department of Infectious Diseases, Bursa Şevket Yilmaz Education and Research Hospital, Bursa, Turkey
Background: Systemic thromboembolism is a serious, major complication in patients with an atrial septal aneurysm (ASA). Paroxysmal atrial fibrillation (AF) is more common in patients with ASA than in the normal population. Neutrophil/lymphocyte ratio (NLR) has been associated with postoperative AF development in patients who have undergone cardiac surgery. This study investigated NLR in a group of ASA patients compared with a control group of healthy volunteers.
Patients and methods: The study group consisted of 40 patients with ASA; the control group consisted of 30 age-, sex-, and body mass index-matched healthy volunteers. All patients and control subjects underwent echocardiographic examination. No patient had a recent history of an acute infection or an inflammatory disease. Baseline NLR was measured by dividing neutrophil count by lymphocyte count.
Results: No statistically significant difference was found between the two groups in terms of basic characteristics. Mean NLR was significantly higher among persons with ASA compared with controls (3.4 ± 1.5 vs 1.6 ± 0.97, P < 0.001).
Conclusion: Our results suggest that a higher NLR, an emerging marker of inflammation, has a positive correlation with ASA. The measurement of NLR may be used to indicate an increased risk of arrhythmia, such as AF, in ASA patients.
Keywords: neutrophil-lymphocyte ratio, inflammation, arrhythmia
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