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Neuropsychiatric assessments in patients with multiple sclerosis in early phases and with low disability

Authors Schmidt SL, Santos da Silva M, Schmidt JJ, Carvalho ALN, Vasconcelos CCF, Paes RA, Boechat YEM, Neder R, Alvarenga RP

Received 23 January 2018

Accepted for publication 11 April 2018

Published 22 June 2018 Volume 2018:14 Pages 1665—1670

DOI https://doi.org/10.2147/NDT.S163480

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Andrew Yee

Peer reviewer comments 4

Editor who approved publication: Dr Roger Pinder


Sergio L Schmidt,1,2 Michele Santos da Silva,2 Juliana J Schmidt,2 Ana Lucia Novais Carvalho,3 Claudia Cristina Ferreira Vasconcelos,2 Renata Alves Paes,2 Yolanda EM Boechat,4 Rafael Neder,2 Regina P Alvarenga2

1Department of Neurophysiology, State University of Rio de Janeiro, RJ, Brazil; 2Neurology Department, Federal University of the State of Rio de Janeiro, RJ, Brazil; 3Department of Psychology, Fluminense Federal University, Niteroi, Brazil; 4Department of Internal Medicine, Fluminense Federal University, Niteroi, Brazil

Background:
In the early phases of multiple sclerosis (MS), patients exhibit slight neuropsychiatric deficits that can only be detected using reliable tools.
Aim: The present investigation aimed to examine neuropsychological performance in 35 patients with incipient MS.
Patients and methods: For the MS group, the inclusion criteria included time of disease <3 years and low disability. The neuropsychological battery consisted of Rey Auditory Learning Test, Controlled Oral Word Association Test, Hooper Visual Organization Test, and Symbol Digit Modalities Test (SDMT).
Results: After correction for the educational level, no significant effect of MS on performance was found for all the tests except for the number of errors of the SDMT (NE-SDMT). Higher levels of education were associated with better performances in all tests, except for the NE-SDMT. MS patients made more errors than the controls.
Conclusion: The effect on the NE-SDMT may reflect difficulties in the ability to inhibit inadequate responses. Patients may exhibit impulsive control disorders in incipient MS, independent of their educational level.

Keywords: processing speed, cognitive impairments, neuropsychology

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