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Neurologic uses of botulinum neurotoxin type A
Published 15 January 2008 Volume 2007:3(6) Pages 785—798
John P Ney, Kevin R Joseph
Madigan Army Medical Center, Neurology Service, Tacoma, WA, USA
Abstract: This article reviews the current and most neurologic uses of botulinum neurotoxin type A (BoNT-A), beginning with relevant historical data, neurochemical mechanism at the neuromuscular junction. Current commercial preparations of BoNT-A are reviewed, as are immunologic issues relating to secondary failure of BoNT-A therapy. Clinical uses are summarized with an emphasis on controlled clinical trials (as appropriate), including facial movement disorders, focal neck and limb dystonias, spasticity, hypersecretory syndromes, and pain.
Keywords: botulinum neurotoxins, BOTOX®, Dysport®, chemodenervation
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