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Nerve growth factor variations in patients with mood disorders: no changes in eight weeks of clinical treatment

Authors Liu X, Zhang T, He S, Hong B, Peng D, Su H, Li F, Tang Y, Lin Z, Fang Y, Jiang K, Li H

Received 19 February 2014

Accepted for publication 3 April 2014

Published 15 May 2014 Volume 2014:10 Pages 835—840

DOI https://doi.org/10.2147/NDT.S62741

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2


Xiaohua Liu,1,* Tianhong Zhang,1,* Shen He,1 Bo Hong,1 Daihui Peng,1 Hui Su,1 Fei Li,1 Yingying Tang,1 Zhiguang Lin,2 Yiru Fang,1 Kaida Jiang1

1Department of Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 2Biochemistry laboratory, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China

*These authors contributed equally to this work

Background: Nerve growth factor (NGF) has received much attention for its role in mood disorders. The primary objective of the present study was to examine serum NGF levels in Chinese inpatients with depressive or manic episodes in the acute phase and to explore the changes in NGF levels after effective clinical treatments.
Methods: One hundred and seven consecutive inpatients and outpatients with mood disorders (30 with unipolar depression, 23 with bipolar depression, and 54 with bipolar mania), and 50 healthy controls were recruited. The serum NGF levels were detected by enzyme-linked immunosorbent assay.
Results: Patients with bipolar mania presented higher serum NGF levels compared to those of healthy controls. After 8 weeks of medical treatment, there were significant improvements in symptoms in patients, but no significant changes in NGF levels.
Conclusion: The present findings may help to strengthen and expand the understanding of the role of NGF in the acute stages of mood disorders.

Keywords: neurotrophins, depression, mania, bipolar disorder, acute phase, clinical sample

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